Our
Projects
Scientific research is an adventure that leads you to explore uncharted territories where no one has ventured before. It is both a privilege and an experience that is humbling and exhilarating at the same time.
Helminth extracellular vesicles and their roles in infection
Extracellular vesicles (EVs) are membrane-bound structures that transport bioactive cargo and are secreted by virtually all living cells into their environment. Functional characterization of the excretory/secretory materials released by helminths at the parasite-host interface—including EVs and their molecular contents—is crucial for understanding how these parasites manipulate their hosts' immune systems to establish chronic infections. Dr. Tritten is particularly dedicated to uncovering the roles of ribonucleic acids (RNA), with a focus on noncoding RNA, in parasite-host communication.
Exploring bacteria-derived noncoding RNAs as anthelmintic agents
Leveraging emerging evidence of inter-kingdom extracellular vesicle exchange and our recent advancements in engineering native transgenic bacteria capable of engrafting in their original mammalian hosts, we aim to investigate the potential of bacteria-produced noncoding RNAs as anthelmintic agents. This work is realized in collaboration with the University of California San Diego and Justus-Liebig University of Giessen.
RNA-based diagnostics of helminth infections in the animal reservoir in endemic countries
We are engaged in several RNA-based diagnostic research projects through interdisciplinary collaborations, notably with Texas A&M University. Developing highly sensitive and specific assays is essential for advancing the elimination phase of nematode pathogens.
